Lysosomal dysfunction in diabetic cardiomyopathy

Diabetes is a major risk factor for a variety of cardiovascular stoneraven d2 complications, while diabetic cardiomyopathy, a disease specific to the myocardium independent of vascular lesions, is an important causative factor for increased risk of heart failure and mortality in diabetic populations.Lysosomes have long been recognized as intracellu

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Ionizing Radiation-Induced Extracellular Vesicle Release Promotes AKT-Associated Survival Response in SH-SY5Y Neuroblastoma Cells

Radiation therapy is one of the most effective methods of tumor eradication; however, in some forms of neuroblastoma, radiation can increase the risk of secondary neoplasms, due to the ability of irradiated cells to transmit pro-survival signals to non-irradiated cells through vesicle secretion.The aims of this study happy camper dog shirt were to

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Using a calibrated multi-zone building model to analyse the impact of occupant behaviour on building performance

Building performance simulation has been commonly used for performance-based building design.However, the simulation accuracy is closely related to the model and input parameters regarding the building physics and occupant behaviour.To check and improve the accuracy of the simulation, the model usually needs to be calibrated using measured data.Unc

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